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MySQL Error: 1194 (Table 'pwn_comment' is marked as crashed and should be repaired)
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发布于:2019-1-8 16:50:52  访问:38 次 回复: 篇
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BMC Healthcare GeneticsTechnical advanceBioMed CentralOpen AccessNeural progenitor cells from an adult patient with fragile X syndromePhilip H Schwartz*1,2,3, Flora Tassone4, Claudia M Greco5, Hubert E Nethercott1, Boback Ziaeian2, Randi J Hagerman6,7 and Paul J HagermanAddress: 1National Human Neural Stem Cell Resource, Children‘s Hospital of NVP-AEW541 InsulinReceptor pubmed ID:https://www.ncbi.nlm.nih.gov/pubmed/26266977 Orange County Analysis Institute, Orange, CA, USA, 2Stem Cell Research, Children‘s Hospital of Orange County Study Institute, Orange, CA, USA, 3Developmental Biology Center, College of Biological Sciences, University of California, Irvine, Irvine, CA, USA, 4Departments of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA, 5Departments of Pathology, University of California, Davis, College of Medicine, Davis, CA, USA, Oroxylin A Purity 6Departments of Pediatrics, University of California, Davis, School of Medicine, Davis, CA, USA and 7M.I.N.D. This can be an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, supplied the original perform is properly cited.AbstractBackground: Currently, there isn‘t any adequate animal model to study the detailed molecular biochemistry of fragile X syndrome, the top heritable kind of mental impairment. In this study, we sought to establish the usage of immature neural cells derived from adult tissues as a novel model of fragile X syndrome that may very well be employed to much more fully recognize the pathology of this neurogenetic illness. Solutions: By modifying published procedures for the harvest of neural progenitor cells in the post-mortem human brain, neural cells had been successfully harvested and grown from post-mortem brain tissue of a 25-year-old adult male with fragile X syndrome, and from brain tissue of a patient with no neurological illness. Results: The cultured fragile X cells displayed several in the qualities of neural progenitor cells, like nestin and CD133 expression, at the same time because the biochemical hallmarks of fragile X syndrome, including CGG repeat expansion as well as a lack of FMRP expression. Conclusion: The productive production of neural cells from an individual with fragile X syndrome opens a brand new avenue for the scientific study with the molecular basis of this disorder, as well as an strategy for studying the efficacy of new therapeutic agents.BackgroundFragile X syndrome, the major heritable form of mental impai.Ull benefit of:?Handy on-line submission ?Thorough peer critique ?No space constraints or color figure charges ?Instant publication on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Analysis that is freely out there for redistributionSubmit your manuscript at www.biomedcentral.com/submit
BMC Medical GeneticsTechnical advanceBioMed CentralOpen AccessNeural progenitor cells from an adult patient with fragile X syndromePhilip H Schwartz*1,2,3, Flora Tassone4, Claudia M Greco5, Hubert E Nethercott1, Boback Ziaeian2, Randi J Hagerman6,7 and Paul J HagermanAddress: 1National Human Neural Stem Cell Resource, Children‘s Hospital of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26266977 Orange County Research Institute, Orange, CA, USA, 2Stem Cell Analysis, Children‘s Hospital of Orange County Investigation Institute, Orange, CA, USA, 3Developmental Biology Center, College of Biological Sciences, University of California, Irvine, Irvine, CA, USA, 4Departments of Biochemistry and Molecular Medicine, University of California, Davis, College of Medicine, Davis, CA, USA, 5Departments of Pathology, University of California, Davis, College of Medicine, Davis, CA, USA, 6Departments of Pediatrics, University of California, Davis, College of Medicine, Davis, CA, USA and 7M.I.N.D.
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